Νanomaterial-Loaded Polymer Coating Prevents the In Vitro Growth of Candida albicans Biofilms on Silicone Biomaterials
نویسندگان
چکیده
Early failure of silicone voice prostheses resulting from fungal colonization and biofilm formation poses a major concern in modern ear nose throat surgery. Therefore, developing new infection prevention techniques to prolong those implants’ survivorship is crucial. We designed an vitro laboratory study include nanomaterial-enhanced polymer coating with plasma spraying technique against Candida albicans growth address this issue. The anti-biofilm effects high- low-dose Al2O3 nanowire TiO2 nanoparticle coatings were studied either alone or conjunction each other using checkerboard testing. It was demonstrated that both nanomaterials capable preventing regardless the anti-fungal agent concentration (median absorbance for high-dose Al2O3-enhanced 0.176 [IQR = 0.207] versus control 0.805 0.381], p 0.003 [98% reduction]; median TiO2-enhanced 0.186 0.024] 0.766 0.458], < 0.001 [93% reduction]). Furthermore, synergy revealed when Bliss model applied. According findings work, it seems simultaneous consideration could further increase existing antibiofilm potential these decrease likelihood localized toxicity.
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ژورنال
عنوان ژورنال: Antibiotics
سال: 2023
ISSN: ['2079-6382']
DOI: https://doi.org/10.3390/antibiotics12071103